Abstract
Epigallocatechin gallate(EGCG) has demonstrated promising effects in promoting the delivery of siRNA by low molecular weight cationic polymers. EGCG can be further hydrolyzed into (-)-epigallocatechin(EGC) and gallic acid(GA) motifs. EGC and GA also have the effect of inhibiting cancer cells, killing tumor cells, and binding proteins or nucleic acids through the combination of hydrogen bonding and hydrophobic interactions. Herein, this study strives to perform a structure-function relationship investigation of plant polyphenol motifs(EGCG, EGC, and GA) in facilitation of condensation and delivery of siRNA by low molecular weight cationic polymers. It was found that EGCG exhibited the highest efficiency in promoting PLL-mediated siRNA delivery while EGC also showed a promising result, and the latter efficiency can be further improved by tailoring the dose of EGC in the complex.
| Translated title of the contribution | Structure-function Relationship of Plant Polyphenols for Promoted siRNA Delivery |
|---|---|
| Original language | Chinese (Traditional) |
| Pages (from-to) | 633-638 |
| Number of pages | 6 |
| Journal | Kao Teng Hsueh Hsiao Hua Heush Hsueh Pao/ Chemical Journal of Chinese Universities |
| Volume | 41 |
| Issue number | 4 |
| DOIs | |
| State | Published - 10 Apr 2020 |
