前列腺素E2受体EP4在心血管疾病中的作用

Sai Lun Wang; Jia Wei Lu; You Fei Guan; Xiao Yan Zhang; Hu Xu

doi:10.13294/j.aps.2019.0011

前列腺素E2受体EP4在心血管疾病中的作用

Translated title of the contribution: Role of prostaglandin E2 receptor 4 in cardiovascular diseases

Sai Lun Wang
, Jia Wei Lu
, You Fei Guan
, Xiao Yan Zhang
, Hu Xu^*

^*Corresponding author for this work

Dalian Medical University

Research output: Contribution to journal › Review article › peer-review

4 Scopus citations

Abstract

Prostaglandin E2 (PGE2) is a cyclooxygenase metabolite of arachidonic acid. It acts as a bioactive lipid and plays an important role in regulating many biological processes. PGE2 binds to 4 different G protein-coupled receptors including prostaglandin E2 receptor subtypes EP1, EP2, EP3 and EP4. The EP4 receptor is widely expressed in most of human organs and tissues. Increasing evidence demonstrates that EP4 is essential for cardiovascular homeostasis and participates in the pathogenesis of many cardiovascular diseases. Here we summarize the role of EP4 in the regulation of cardiovascular function and discuss potential mechanisms by which EP4 is involved in the development of cardiovascular disorders with a focus on its effect on inflammation.

Translated title of the contribution	Role of prostaglandin E2 receptor 4 in cardiovascular diseases
Original language	Chinese (Traditional)
Pages (from-to)	361-370
Number of pages	10
Journal	Acta Physiologica Sinica
Volume	71
Issue number	2
DOIs	https://doi.org/10.13294/j.aps.2019.0011
State	Published - 25 Apr 2019
Externally published	Yes

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10.13294/j.aps.2019.0011

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title = "前列腺素E2受体EP4在心血管疾病中的作用",

abstract = "Prostaglandin E2 (PGE2) is a cyclooxygenase metabolite of arachidonic acid. It acts as a bioactive lipid and plays an important role in regulating many biological processes. PGE2 binds to 4 different G protein-coupled receptors including prostaglandin E2 receptor subtypes EP1, EP2, EP3 and EP4. The EP4 receptor is widely expressed in most of human organs and tissues. Increasing evidence demonstrates that EP4 is essential for cardiovascular homeostasis and participates in the pathogenesis of many cardiovascular diseases. Here we summarize the role of EP4 in the regulation of cardiovascular function and discuss potential mechanisms by which EP4 is involved in the development of cardiovascular disorders with a focus on its effect on inflammation.",

keywords = "EP4, cardiovascular disease, inflammation, prostaglandin E2, signal transduction",

author = "Wang, \{Sai Lun\} and Lu, \{Jia Wei\} and Guan, \{You Fei\} and Zhang, \{Xiao Yan\} and Hu Xu",

year = "2019",

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day = "25",

doi = "10.13294/j.aps.2019.0011",

language = "繁体中文",

volume = "71",

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TY - JOUR

T1 - 前列腺素E2受体EP4在心血管疾病中的作用

AU - Wang, Sai Lun

AU - Lu, Jia Wei

AU - Guan, You Fei

AU - Zhang, Xiao Yan

AU - Xu, Hu

PY - 2019/4/25

Y1 - 2019/4/25

N2 - Prostaglandin E2 (PGE2) is a cyclooxygenase metabolite of arachidonic acid. It acts as a bioactive lipid and plays an important role in regulating many biological processes. PGE2 binds to 4 different G protein-coupled receptors including prostaglandin E2 receptor subtypes EP1, EP2, EP3 and EP4. The EP4 receptor is widely expressed in most of human organs and tissues. Increasing evidence demonstrates that EP4 is essential for cardiovascular homeostasis and participates in the pathogenesis of many cardiovascular diseases. Here we summarize the role of EP4 in the regulation of cardiovascular function and discuss potential mechanisms by which EP4 is involved in the development of cardiovascular disorders with a focus on its effect on inflammation.

AB - Prostaglandin E2 (PGE2) is a cyclooxygenase metabolite of arachidonic acid. It acts as a bioactive lipid and plays an important role in regulating many biological processes. PGE2 binds to 4 different G protein-coupled receptors including prostaglandin E2 receptor subtypes EP1, EP2, EP3 and EP4. The EP4 receptor is widely expressed in most of human organs and tissues. Increasing evidence demonstrates that EP4 is essential for cardiovascular homeostasis and participates in the pathogenesis of many cardiovascular diseases. Here we summarize the role of EP4 in the regulation of cardiovascular function and discuss potential mechanisms by which EP4 is involved in the development of cardiovascular disorders with a focus on its effect on inflammation.

KW - EP4

KW - cardiovascular disease

KW - inflammation

KW - prostaglandin E2

KW - signal transduction

UR - https://www.scopus.com/pages/publications/85065087721

U2 - 10.13294/j.aps.2019.0011

DO - 10.13294/j.aps.2019.0011

M3 - 文献综述

C2 - 31008497

AN - SCOPUS:85065087721

SN - 0371-0874

VL - 71

SP - 361

EP - 370

JO - Acta Physiologica Sinica

JF - Acta Physiologica Sinica

IS - 2

ER -

前列腺素E2受体EP4在心血管疾病中的作用

Abstract

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