TY - JOUR
T1 - 光遗传学工具的开发及其应用研究
AU - Wei, Qiyao
AU - Xu, Chenchen
AU - Wang, Meiyan
AU - Ye, Haifeng
N1 - Publisher Copyright:
© 2019, Science Press. All right reserved.
PY - 2019/12/25
Y1 - 2019/12/25
N2 - Dynamic variations of the cell microenvironment can affect cell differentiation, cell signaling pathways, individual growth, and disease. Optogenetics combines gene-encoded protein expression with optical controlling, and offers a novel, reversible, non-invasive and spatiotemporal-specific research tool to dynamically or reversibly regulate cell signaling pathways, subcellular localization and gene expression. This review summarizes the types of optogenetic components and the involved cellular signaling pathways, and explores the application and future prospects of the light-controlled cell signaling pathways.
AB - Dynamic variations of the cell microenvironment can affect cell differentiation, cell signaling pathways, individual growth, and disease. Optogenetics combines gene-encoded protein expression with optical controlling, and offers a novel, reversible, non-invasive and spatiotemporal-specific research tool to dynamically or reversibly regulate cell signaling pathways, subcellular localization and gene expression. This review summarizes the types of optogenetic components and the involved cellular signaling pathways, and explores the application and future prospects of the light-controlled cell signaling pathways.
KW - Light-controlled gene switch
KW - Light-controlled signal transduction
KW - Optogenetics
KW - Spatiotemporal control
KW - Synthetic biology
UR - https://www.scopus.com/pages/publications/85077029098
U2 - 10.13345/j.cjb.190298
DO - 10.13345/j.cjb.190298
M3 - 文章
C2 - 31880133
AN - SCOPUS:85077029098
SN - 1000-3061
VL - 35
SP - 2238
EP - 2256
JO - Shengwu Gongcheng Xuebao/Chinese Journal of Biotechnology
JF - Shengwu Gongcheng Xuebao/Chinese Journal of Biotechnology
IS - 12
ER -